The program, which is executive produced by veteran journalist Jove Francisco, will be headlined by The World Tonight's Teddy Boy Locsin and UP Professor and political analyst Prospero "Popoy" De Vera.
ANC's multimedia reporter and 2015 MNP media winner Christian Esguerra is also taking part as the program's head writer.
#NoFilter is among the Kapamilya news channel's newest offering this first quarter of 2016, along with Cathy Yang's new weekly business program, The Boss, which premiered Wednesday night.
The program will have a replay every Friday at 1:30AM and 2:30PM and on weekends on ANC.
Prospero De Vera and Teddy Boy Locsin at the ANC Rockwell studio
(Correction: An earlier version of this post incorrectly stated the time slot of the program.)